This is perhaps inspired by The Haunted Mouse, and to an equal extent by WarioWare: Smooth Moves and WarioWare: Twisted!. Keep the rodent player-character from being zapped, even as your mouse controls are periodically rotated 90 degrees, requiring you to rotate your in-real-life mouse to compensate.

The Windows version works a bit better than the HTML5 version, insofar as the latter can’t register the mouse’s movement if the pointer drifts out of the screen region. – [Author’s post on Glorious Trainwrecks]